UTIs can be prevented with an antiseptic drug


A coloured scanning electron micrograph of Escherichia coli (E. coli) bacteria on bladder cells in a urine sample from a patient with a urinary tract infection

A colored scanning electron micrograph of Escherichia coli (E. coli) micro organism on bladder cells in a urine pattern from a affected person with a urinary tract an infection


An antiseptic drug that inhibits the expansion of micro organism in urine could also be as efficient as antibiotics within the prevention of recurring urinary tract infections (UTIs).

“Over 50 per cent of girls will endure from a urinary tract an infection of their lifetimes,” says Chris Harding at The Newcastle upon Tyne Hospitals NHS Basis Belief. As much as a 3rd of those ladies expertise recurrent infections, he says, outlined as not less than three UTI episodes a yr.

UK tips advocate a every day low-dose antibiotic as a preventative remedy for recurrent UTIs. Nonetheless, long-term use of those medicine raises the chance of antibiotic resistance. Not like antibiotics, which kill micro organism or forestall them from spreading, methenamine hippurate sterilises urine, inhibiting the expansion of sure micro organism. The antiseptic has proven promise for UTI prevention, however the proof is inconclusive.

To study extra, Harding and his colleagues studied 205 ladies who had on common six UTIs a yr. Day by day for 12 months, 102 of the members took an antibiotic, whereas the remaining 103 got a methenamine hippurate tablet.

Over the yr, these within the antibiotic group had on common 0.89 UTI episodes, in contrast with 1.38 episodes amongst these taking methenamine hippurate.

“There was mainly no distinction in outcomes between the 2 strategies,” says Harding. “If we wish to scale back the usage of antibiotics to fight antimicrobial resistance, then trials like this present clinicians and sufferers a reputable non-antibiotic possibility for prevention.”

Nonetheless, the long-term security of methenamine hippurate is unclear. 4 of the members who took it every day had been admitted to hospital because of a UTI, and 6 of the identical group reported a fever throughout an an infection. Total, 34 folks within the antibiotic group and and 35 within the antiseptic group had uncomfortable side effects, most of which had been gentle.

The examine was additionally not blinded, so the members and researchers had been conscious of the remedy acquired. Completely different antibiotics had been additionally prescribed in response to every particular person’s medical historical past, which can have affected the outcomes.

Nonetheless, rising considerations round antibiotic resistance might make methenamine hippurate a viable preventative possibility if future analysis helps its use, a staff of Australian researchers stated in an editorial linked to the examine.

“A whole bunch of hundreds of individuals get UTIs yearly,” says Jennifer Rohn at College School London. “So it’s a critical stress level on the antimicrobial resistance disaster as a result of so many antibiotic prescriptions are prescribed… so something that may knock down the variety of prescriptions is an efficient factor.”

Journal reference: The BMJ, DOI: 10.1136/bmj-2021-068229

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